After that we need to de compress it and put in a folder

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pandora jewellery After adjusting for age, body mass index, race, and other factors, the relative risk of primary hyperparathyroidism for women in the group with the highest intake of dietary calcium was 0.56 (95% confidence interval 0.37 to 0.86, P=0.009 for trend), compared with the group with the lowest intake. The multivariable relative risk of primary hyperparathyroidism for women taking more than 500 mg/day of calcium supplements compared with no calcium supplements was 0.41 (95% confidence interval 0.29 to 0.60, PConclusion Increased calcium intake is independently associated with a reduced risk of primary hyperparathyroidism in women.IntroductionPrimary hyperparathyroidism is the most common cause of hypercalcemia1 and the third most common endocrine disorder, with 100000 new cases in the United States each year.2 Up to 2% of postmenopausal women could have this condition.3 4 Primary hyperparathyroidism is characterized by hypercalcemia with a high or insufficiently suppressed level of parathyroid hormone, and is caused by a solitary parathyroid adenoma in 85 90% of patients.5 6 Associated morbidities and costly sequelae include decreased bone mineral density, fractures, and kidney stones.7 8 However, little is known about risk factors for primary hyperparathyroidism.9 Monogenic disorders (such as multiple endocrine neoplasia I and II)10 account for fewer than 5% of cases,11 and neck irradiation also accounts for only a small fraction of cases.12Because the parathyroid adenoma of sporadic primary hyperparathyroidism is monoclonal,13 14 15 factors that chronically stimulate parathyroid hormone and increase the probability of a parathyroid cell undergoing a somatic mutation and subsequent clonal proliferation could increase the risk for primary hyperparathyroidism.11 14 16 Calcium intake is known to influence parathyroid hormone level17 18 19 20 21 22 and therefore could be important in the pathogenesis of primary hyperparathyroidism. However, no study to date has prospectively explored the relation between calcium intake and risk of developing primary hyperparathyroidism.To examine the association between calcium intake and the risk of incident primary hyperparathyroidism, we conducted a prospective study of 58354 women in the Nurses’ Health Study I without history of primary hyperparathyroidism at baseline.MethodsStudy populationThe Nurses’ Health Study I is an ongoing, prospective cohort study which began in 1976, enrolling 121700 female registered nurses between 30 and 55 years of age and residing in 11 US states pandora jewellery.

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